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An Intimate History
Starred review from February 29, 2016
In skillful prose, Mukherjee, an oncologist and the Pulitzer Prizeâwinning author of The Emperor of All Maladies, relates the grand tale of how scientists have come to understand the role genes play in human development, behavior, and physiology. He deftly relates the basic scientific facts about the way genes are believed to function, while making clear the aspects of genetics that remain unknown. Mukherjee offers insight into both the scientific process and the sociology of science, exploring the crucial experiments that have shed light on the biochemical complexities inherent in the genome. He also examines many of the philosophical and moral quandaries that have long swirled around the study of genetics, addressing such important topics as eugenics, stem cell research, and what it means to use the composition of a person's genotype to make predictions about his or her health or behavior. Looking to the future, Mukherjee addresses prospects for medical advances in the treatment of diseases and in selectingâor actively craftingâthe genetic composition of offspring, regularly pointing out the pressing ethical considerations. Throughout, he repeatedly poses the question, "What is ânatural'?" declining to offer a single answer, in recognition that both context and change are essential. By relating familial information, Mukherjee grounds the abstract in the personal to add power and poignancy to his excellent narrative.
July 25, 2016
Veteran voice actor Boutsikaris’s talents are on full display in the audio edition of the latest from oncologist and Pulitzer Prize–winning author Mukherjee. He uses vocal flexibility to stress phrases, words, and even syllables to illuminate the grand tale of how scientists have come to understand the role genes play in human development, behavior, and physiology. Boutsikaris has such control of grammatical structure that every sentence, no matter the length, is clear, and he includes frequent transitional pauses that help the listener retain focus all the way through Mukherjee’s complex but fascinating narrative, chronicling breakthroughs in the quest to understand human heredity, from the work of Darwin and Mendel to current research in the field of genetics. A Scribner hardcover.
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